Medicine

- Mendeley Supplemental Figure 1. Representative examples of the test. Each image was presented six times under different instructions: a neutral baseline prompt, and five framed prompts. - Mendeley Supplemental File 1. Detailed Materials and methods (Study design, Model Access and Interaction, Dataset Details, Prompting Procedure, Outcome Measures and Statistical Analysis) of the study

RNA-seq raw count matrix from Orthotopic human immune system reconstituted (HIR) patient-derived xenograft (PDX) PDAC mouse models. metadata file match sample IDs and treatment conditions

DATA from "Psychopathological burden and coping strategies among Italian healthcare workers facing the COVID-19 emergency: data from the COMET collaborative network "

We addressed the accuracy of Lung Ultrasound (LUS) to detect pneumothorax in children with acute chest pain evaluated in the pediatric Emergency Department (pED). Methods We prospectively analyzed patients from 5 to 17 years of age with acute chest pain and clinical suspicion of pneumothorax (PNX) evaluated at a tertiary level pediatric hospital. After clinical examination and before Chest X-Ray (CXR), children underwent LUS to evaluate the presence of PNX. Results We enrolled 77 children, 44 (57,1 %) male, with median age of 10 years and 3 months (IQR 6 years and 9 months - 14 years and 2 months). Thirty (39%) children had interstitial lung disease; 20/77 (26%) had pneumonia with or without pleural effusions; 7/77 (9,1%) had thoracic trauma; 7/77 (9,1%) had a final diagnosis of myo/pericarditis and 13 (16,9%) received a final diagnosis of PNX. In all 13 patients LUS showed the “bar-code sign” while in 12 (92,3%) there was the lung point, giving a diagnosis of PNX. All cases were confirmed by CXR. The lung point had a sensitivity of 92,3% and a specificity of 100%, a positive predictive value of 100% and a negative predictive value of 98,4 % for the detection of PNX. The “bar-code sign” had a sensitivity of 100% and a specificity of 100%, a positive predictive value of 100% and a negative predictive value of 100% for the detection of PNX. Conclusions LUS is highly accurate in detecting or excluding pneumothorax in children with acute chest pain evaluated in the pediatric emergency department. Importantly, both lung-point and M-mode need to be performed when PNX is suspected.